Human Reference Gut Microbiome (HRGM) is an updated human gut microbiome catalog by including newly assembled 29,082 genomes on 845 fecal samples collected from three under-represented Asian countries—Korea, India and Japan. The HRGM provides 232,098 nonredundant genomes for 5,414 representative prokaryotic species, >103 million proteins and >274 million single nucleotide variants (SNVs), achieving over 10% increase in size from of the existing database. HRGM significantly improves taxonomic and functional classification of sequencing reads from fecal samples.

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Human reference gut microbiome of 5,414 prokaryotic species including newly assembled genomes from under-represented Asian metagenomes, submitted